Over the adult lifespan, brain structure and function change dynamically driven by genetic and environmental factors. Importantly, healthy brain aging has also been increasingly recognised to depend on (mid-life) lifestyle factors. As effective strategies to combat accelerated age-related cognitive decline and dementia are missing, effective prevention becomes more and more important. Consequently, there is a growing interest in better understanding the modifiers and mechanisms which influence brain health in aging and disease. At the conference “Brain plasticity - influences of lifestyle and aging”, four distinguished researchers in the field will present their latest findings on genetic and lifestyle factors, with a special focus on diet, and their impact on brain plasticity. Subsequently, presentation sessions will be held with short presentations by early-career researchers, followed by room for discussion with their peers and senior researchers.